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Research And Education Center

The Premier Indonesian Teaching and Research Center For Cleft and Craniofacial

The long standing education and research center for craniofacial fields in Indonesia. Cleft Craniofacial Center is under the auspisces of Plastic Surgery Division Cipto Mangunkusumo Hospital and Faculty Of Medicine Universitas Indonesia.

The University has trained more than hundreds of Indonesian plastic surgeon since the twentieth century, the education excelence is also supported by the abundance of craniofacial cases in Indonesia. The CCC is also considered the leading craniofacial center in Indonesia who provide training for medical professionals in cleft and craniofacial fields.

As an educational center, we support the development and advancement of knowledge and techniques of reconstructive surgeries. We are striving to always produce novel findings and high-quality publications. Our contribution to the vastly evolving knowledge and skills in plastic reconstructive and aesthetic surgery are depicted in the form of local and international publications written by our aspiring consultants and residents. Some of the published manuscripts are featured below.

We are also welcoming all medical professional and researcher who might be interested in craniofacial fields to contact us and join our research project.

 

The Effect of Perichondrium and Graft Modification on the Viability of Conchal Cartilage Graft: An Experimental Study in Rabbit 

Nathania Pudya Hapsari, Kristaninta Bangun, Parintosa Atmodiwirjo, Bambang Ponco, Tri Isyani Tungga Dewi, and Jessica Halim in Cleft Palate-Craniofacial Journal

Objective: Cartilage grafts are widely used in reconstructing nasal deformity for structural and aesthetic purposes. Despite being immunologically privileged, cartilage grafts are susceptible to volume loss with high risk of resorption over time. Therefore, experts opt for cartilage handling modification to resolve this issue through graft dicing, wrapping, or perichondrium preservation. This study will evaluate the effect cartilage graft preparations on graft viability. Design: Single-randomized post-test-only study design. Setting: Animal Hospital at Bogor Agricultural Institute. Participants: Six New Zealand, male, Hycole rabbits. Intervention: Conchal cartilage grafts were retrieved from 6 experimental rabbits and distributed into 3 treatment groups: diced cartilage graft (DC; control), one-sided perichondrium-attached scored cartilage (OPSC), and tube-shaped perichondrium- wrapped diced cartilage (TPDC). Main Outcome Measures: Macroscopic (weight and contour) and microscopic (chondroblast proliferation, graft thickness, apoptotic cells) evaluation through histological measures were recorded on week 12. Statistical analysis was done to compare between groups. Results: Diced cartilage and OPSC groups showed significant weight changes on week 12 (P < .05) with OPSC presenting with the biggest difference. Diced cartilage and OPSC group showed moderate cell proliferation on week 12 while TPDC displayed most abundant apoptotic cells (5.8%; P < .05). Diced cartilage group had the highest cartilage thickness ratio (P < .05). Discussion: Bare DC technique promoted graft thickness while perichondrium-attached scored cartilage showed the most abundant chondroblast proliferation and the least apoptotic cells. Perichondrium contributes to enhanced new cartilage formation. Conclusion: Diced cartilage graft is suitable for masking irregularity and volume augmentation, while perichondrium-attached cartilage graft is better for structural support in nasal reconstruction.

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